Knockout mouse model is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by deleting portions of the gene’s DNA sequence, or by replacing the gene with an altered DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important clues about the function of individual genes. Mice and humans share many genes in common. Hence, information from knockout mouse models can shed light on the biological roles of specific genes as well as on the involvement of those genes in human disease.
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Strain Name：C57BL/6Smoc-Cdkl5em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2105744
Disease Connection：developmental and epileptic encephalopathy 2
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Strain Name：C57BL/6Smoc-Cdkn1aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190774
Disease Connection：systemic lupus erythematosus, hepatocellular carcinoma
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Strain Name：C57BL/6Smoc-Cdkn1aem2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-226095
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Strain Name：C57BL/6Smoc-Cdkn1bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200622
Research Application：Cell cycle research; multiple endocrine neoplasia type IV (MEN4) research
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Strain Name：C57BL/6Smoc-Cdkn2aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-240239
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Strain Name：C57BL/6Smoc-Cdkn2aem2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190633
Disease Connection：malignant peripheral nerve sheath tumor
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Strain Name：C57BL/6Smoc-Cdkn2Bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190621
Research Application：This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.
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Strain Name：C57BL/6Smoc-Cdkn2Cem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2114003
Disease Connection：medulloblastoma
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