Knockout mouse model is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by deleting portions of the gene’s DNA sequence, or by replacing the gene with an altered DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important clues about the function of individual genes. Mice and humans share many genes in common. Hence, information from knockout mouse models can shed light on the biological roles of specific genes as well as on the involvement of those genes in human disease.
|
|
||
|
|
||
|
|
Strain Name：C57BL/6Smoc-Calcrem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-231365
|
|
|
|
Strain Name：C57BL/6Smoc-Calcrlem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-202020
|
|
|
|
||
|
|
||
|
|
||
|
|
||
|
|
||
|
|
Strain Name：C57BL/6Smoc-Calm1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190703
Research Application：The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14.
|
