hCXCR6

Nomenclature

C57BL/6Smoc-Cxcr6em(hCXCR6)Smoc

Cat. NO.

NM-HU-215001

Strain State

Repository Live

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Model Description

The endogenous mice Cxcr6 gene was replaced by human CXCR6 gene.

Validation Data

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Fig1. Detection of CXCR6 expression in spleen  by RT-PCR. Wild type: only one band at 423 bp with primers F1/R1(mCxcr6);Homozygous: only one band at 206 bp with primers F2/R2(hCXCR6); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. Detection of hCXCR6 expression on NKT cells in spleen in hCXCR6 KI mice.

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Fig3. Detection of hCXCR6 expression on splenocyte-derived activated T cells in hCXCR6 KI mice. 

Note. Splenocytes from C57BL/6 and homozygous hCXCR6 mice were stimulated with anti-mCD3 and anti-mCD28 in vitro. 




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