Rag2-KO

Nomenclature

C57BL/6Smoc-Rag2em2Smoc

Cat. NO.

NM-KO-190429

Strain State

Repository Live

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Gene Summary

Gene Symbol
Rag2

Synonyms

Rag-2

NCBI ID

19374 

MGI ID

97849

Ensembl ID

ENSMUSG00000032864

Pubmed

Rag2

Human Ortholog

RAG2

Model Description

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.
Research Application：Immunodeficiency,tumor-bearing model

Validation Data

FACS detection of T and B cells collected from Rag2 knockout mice

Figure 1. Loss of T,B cells in Rag2(-/-) mice.

Splenocytes and blood cells of Rag2 knockout mice were isolated. Fractions of T and B cells were characterized using flow-cytometry. 

Publications

E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases
References：The Journal of Clinical Investigation

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
References：iScience

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