hICOS/hICOSL

Nomenclature

C57BL/6Smoc-Icoslem1(hICOSLG) Icosem1(hICOS)/Smoc

Cat. NO.

NM-HU-18018

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol

Synonyms

AILIM CCLP CRP-1 H4 Ly115，B7h GI50 GL50 B7-H2 LICOS B7RP-1 GL50-B ICOS-L Icoslg Ly115l AU044799 BG071784 mKIAA0653

NCBI ID

54167，50723

MGI ID

1858745，1354701

Ensembl ID

ENSMUSG00000026009，ENSMUSG00000000732

Pubmed

Human Ortholog

ICOS，ICOSLG

Model Description

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

image.png

Fig1. Detection of hICOSL expression on activated APCs in hICOSL KI mice and hICOS/hICOSL dKI mice. 

Note. The splenocyte-derived activated APCs were stimulated by LPS in vitro.

image.png

Fig2. Detection of hICOS expression on splenocyte-derived activated T cells in hICOS/hICOSL dKI mice.



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