hCD79B

Nomenclature

C57BL/6Smoc-Cd79btm2(hCD79B )Smoc

Cat. NO.

NM-HU-2000012

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
CD79b

Model Description

The endogenous mouse Cd79b gene was replaced by human CD79B gene.
Research Application:Immunotherapy,cancer research,drug screening

Validation Data

image.png

Fig.1 Detection of CD79B expression on B cells in blood and spleen of WT C57BL/6 mice and HO hCD79B mice by FACS. Leukocytes were collected from wild-type C57BL/6 mice (female, 7 weeks old) and homozygous hCD79B humanized mice (male, 9 weeks old), and analyzed by flow cytometry with anti-mCD79B and anti-hCD79B. hCD79B was exclusively detectable in hCD79B humanized mice but not in wild-type mice. hCD79B was exclusively detectable on B cells in hCD79B humanized mice, whereas mCD79B was exclusively detectable on B cells in wild-type C57BL/6 mice.


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more