hFCRN

Nomenclature

C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc

Cat. NO.

NM-HU-00109

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Fcgrt

Synonyms

FcRn

NCBI ID

14132

MGI ID

103017

Ensembl ID

ENSMUSG00000003420

Pubmed

Fcgrt

Human Ortholog

FCGRT

Model Description

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.
Research Application：cancer research,Immunotherapy,drug screening

Validation Data

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Fig1.The expression of mouse FCGRT and human FCGRT in liver was confirmed by western blotting.

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Fig2. PK validation of human antibody (ustekinumab and briakinumab) in FCGRT humanized Mice.

Publications

Self-assembly of X-shaped antibody to combine the activity of IgG and IgA for enhanced tumor killing
References：Theranostics

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