hTWEAK/hAPRIL

Nomenclature

C57BL/6Smoc-Tnfsf12/Tnfsf13tm1(hTNFSF12/hTNFSF13)Smoc

Cat. NO.

NM-HU-234421

Strain State

Repository Live

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Gene Summary

Gene Symbol
Tnfsf12

Synonyms

Dr3l; Apo3l; Dr3lg; Tweak

Chromosome

11

NCBI ID

21944

MGI ID

1196259

Ensembl ID

ENSMUSG00000097328

Pubmed

Tnfsf12

Model Description

The endogenous mouse Tnfsf12/Tnfsf13 gene was replaced by human TNFSF12/TNFSF13 gene.

Validation Data

image.png

Fig.1 Detection of TNFSF12 and TNFSF13 expression in lung by RT-PCR. 

Wild type: one band at 142 bp with primers F1/R1(mTnfsf12) and one band at 180 bp with primers F3/R3(mTnfsf13);

Homozygous: one band at 173 bp with primers F2/R2(hTNFSF12) and one band at 217 bp with primers F4/R4(hTNFSF13).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human APRIL expression in lymph gland in hTWEAK/hAPRIL knockin mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.

image.png

Fig.3 Detection of human TWEAK expression in lymph gland in hTWEAK/hAPRIL knockin mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.

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