Wnt1-Dre

A Dre-Wpre-polyA expression cassette was knocked into the Wnt1 gene start codon site. Wnt1 gene is involved in stem cell poliferation in multiple systems, including the hematopoietic system and the embryonic nervous system. This strain may be useful for studying central nervous system development. When crossed with a strain carrying a gene flanked by rox sites, the flanked gene will be removed in cells expressing dre.

Fig. 1 Dre-mediated recombination in the brain of Wnt1^Dre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the cerebellar purkinje cells and epithalamus cells of Wnt1^Dre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Dre-mediated recombination in the brain of Wnt1^Dre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in some cells of the ventricle of Wnt1^Dre/+; Rosa26^tdTomato/+ mouse.

Fig. 3 Detection of tdTomato(red) in various tissues of Wnt1^Dre/+; Rosa26^tdTomato/+ mice. Dre mediated recombination can be detected in some cells of the lung, salivary gland, brain, eyes, stomach, thymus, colon, intestinal crypt, ovary, liver and pancreas. Tdtomato expression can not be observed in the brown fat, heart, kidney, spleen or muscle. (For more detailed information please contact our technical advisor.)