Penk-IRES-Cre

Nomenclature

C57BL/6Smoc-Penkem1(IRES2-iCre)Smoc

Cat. NO.

NM-KI-200088

Strain State

Sperm cryopreservation

Export PDF

Gene Summary

Gene Symbol
Penk

Synonyms

ENK; PPA; Penk1; AI326464

NCBI ID

18619

MGI ID

104629

Ensembl ID

ENSMUSG00000045573

Pubmed

Penk

Human Ortholog

PENK

Model Description

A IRES2-iCre expression cassette was knocked into the Penk gene stop codon site.
Research Application：Penk gene encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. The gene product is involved in regulating synaptic plasticity, a crucial neurochemical mechanism underlying learning and memory.

Validation Data

NM-KI-200088 Penk-IRES-Cre-1.png

Fig. 1 Cre-mediated recombination in the brain of PenkCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the brain of PenkCre/+; Rosa26tdTomato/+ mouse.

NM-KI-200088 Penk-IRES-Cre-2.png

Fig. 2 Detection of tdTomato(red) in various tissues of  PenkCre/+; Rosa26tdTomato/+ mice. Tdtomato is expressed throughout the brain. And cre-mediated recombination can be detected in some cells of the pituitary gland, kidney, intetstine, colon, retina, brown fat, testis, epididymis, salivary gland, stomach, thymus, lung, heart, liver and skin. (For more detailed information please contact our technical advisor.)

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Workshop：Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more