NVG-hIL15

Nomenclature

NOD-PrkdcscidIl2rgem1Il15(hIL15)Smoc

Cat. NO.

GM-NVG-210001

Strain State

Repository Live

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Model Description

The endogenous mice Il15 gene was replaced by human IL15 gene.
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

Human IL15 expression analysis

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Fig 1. Human IL15 expression analysis in homozygous NVG-hIL15 mice by ELISA. 

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Fig 2. Humanized immune reconstitution levels and body weight growth curves in huPBMC-NVG-hIL15 mice.

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Fig 3. Humanized immune reconstitution levels in huPBNK-NVG-hIL15 mice.

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Fig 4. Efficacy evaluation of CD20-targeting antibody using Raji huPBNK model.

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Fig 5. Functional protein detection in NK cells in the presence of anti-hCD20 antibody drug using Raji huPBNK model.

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Fig 6. ADCC efficacy research in vitro using huPBNK model.

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Fig 7. Body weight growth curves in γδT-NVG-hIL15 mice.

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Fig 8. Survial rates in γδT-NVG-hIL15 mice.

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Fig 9. Humanized immune reconstitution levels in γδT-NVG-hIL15 mice.

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Fig 10. Humanized immune reconstitution levels in huHSC-NVG-hIL15 mice. A. hCD45+ cell and mCD45+ cell in PB. B. hCD3+, hCD19+, hCD56+, hCD33+, hCD33+hCD14+, hCD33+ hCD66b+ cell in hCD45+ cell. 

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