In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
|
|
||
|
|
Strain Name：C57BL/6JSmo-Irf1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2102684
|
|
|
|
Strain Name：C57BL/6JSmo-Irf2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2101605
|
|
|
|
||
|
|
Strain Name：C57BL/6JSmo-Irf2bp2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2113191
|
|
|
|
Strain Name：C57BL/6JSmo-Irf2bplem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-260085
|
|
|
|
Strain Name：C57BL/6JSmo-Irf3em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2107952
|
|
|
|
Strain Name：C57BL/6JSmo-Irf4em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200190
Research Application：Related research on preimplantation embryo and IL4-mediated signal transduction events
|
|
|
|
Strain Name：C57BL/6JSmo-Irf5em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200191
Research Application：Direct p53 effector and Toll-like receptor signaling pathway related research
|
|
|
|
Strain Name：C57BL/6JSmo-Irf6em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-242215
Disease Connection：cleft lip
|
