Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

Mice
Strain Name:C57BL/6Smoc-Flnbem1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-242467
Mice
Strain Name:C57BL/6Smoc-Flncem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-241584
Mice
Strain Name:C57BL/6Smoc-Flot1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-241059
Mice
Strain Name:C57BL/6Smoc-Flot2em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Flrt1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2105530
Mice
Strain Name:C57BL/6Smoc-Flrt2em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-241810
Mice
Strain Name:C57BL/6Smoc-Flrt3em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Flt1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231278
Mice
Strain Name:C57BL/6Smoc-Flt1em2(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-240237
Mice
Strain Name:C57BL/6Smoc-Flt3em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231301
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