In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
|
|
||
|
|
||
|
|
Strain Name：C57BL/6Smoc-Crb1em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
Disease Connection：Leber congenital amaurosis 8
|
|
|
|
Strain Name：C57BL/6Smoc-Crb2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-226441
|
|
|
|
||
|
|
Strain Name：C57BL/6Smoc-Crbnem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
Disease Connection：autosomal recessive non-syndromic intellectual disability
|
|
|
|
||
|
|
||
|
|
Strain Name：C57BL/6Smoc-Creb1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-250321
|
|
|
|
Strain Name：C57BL/6Smoc-Creb3em(flox)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-220247
|
