Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

Mice
Strain Name:C57BL/6Smoc-Vcptm1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231802
Mice
Strain Name:C57BL/6Smoc-Vcpip1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Vcpkmtem1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-205216
Mice
Strain Name:C57BL/6Smoc-Vdac1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-234601
Mice
Strain Name:C57BL/6Smoc-Vdac2em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-252030
Mice
Strain Name:C57BL/6Smoc-Vdac3em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Vdrem1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-210040
Mice
Strain Name:C57BL/6Smoc-Vegfatm1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-234739
Mice
Strain Name:C57BL/6Smoc-Vegfbem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-233978
Mice
Strain Name:C57BL/6Smoc-Vegfcem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231292
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