Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

Mice
Strain Name:C57BL/6Smoc-Usp51em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-226371
Mice
Strain Name:C57BL/6Smoc-Usp53em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2104492
Mice
Strain Name:C57BL/6Smoc-Usp54em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-253827
Mice
Strain Name:C57BL/6Smoc-Usp6nlem1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-205100
Mice
Strain Name:C57BL/6Smoc-Usp7em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2100696
Mice
Strain Name:C57BL/6Smoc-Usp8em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2102221
Mice
Strain Name:C57BL/6Smoc-Usp9xem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-205126
Mice
Strain Name:C57BL/6Smoc-Usp9yem1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Uspl1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Ustem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-251550
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