In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
|
|
||
|
|
||
|
|
||
|
|
||
|
|
||
|
|
Strain Name：C57BL/6Smoc-Ttnem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-2100892
Disease Connection：autosomal recessive limb-girdle muscular dystrophy type 2J
|
|
|
|
||
|
|
Strain Name：C57BL/6Smoc-Ttpalem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-226025
|
|
|
|
Strain Name：C57BL/6Smoc-Ttrem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-226502
|
|
|
|
