In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Trp53tm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18005
Disease Connection：medulloblastoma, breast cancer, prostate cancer, central nervous system cancer, osteosarcoma, pancreatic carcinoma, malignant astrocytoma, thyroid gland carcinoma, ovarian cancer, urinary bladder cancer, alveolar rhabdomyosarcoma, glioblastoma, pancreatic ductal adenocarcinoma, squamous cell carcinoma, thyroid gland cancer, CHARGE syndrome, stomach cancer, invasive lobular carcinoma, endometrial cancer, hereditary breast ovarian cancer syndrome, pancreatic mucinous cystadenoma
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Strain Name：C57BL/6Smoc-Trp53tm2(flox)Krasem4(LSL-G12D)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-233079
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