In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Tgfbr1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200142
Disease Connection：head and neck squamous cell carcinoma, osteoarthritis
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Strain Name：C57BL/6Smoc-Tgfbr2tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200026
Disease Connection：cleft soft palate, prostate cancer
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Strain Name：C57BL/6Smoc-Tgfbr2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200228
Disease Connection：cleft soft palate, prostate cancer
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Strain Name：C57BL/6Smoc-Tgfbr3em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-252774
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Strain Name：C57BL/6Smoc-Tgif1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-205202
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Strain Name：C57BL/6Smoc-Tgm2em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200229
Research Application：Research on phospholipase C pathway and respiratory electron transport, ATP synthesis through chemical permeation coupling, and heat generation through uncoupling proteins
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