In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
|
|
||
|
|
||
|
|
||
|
|
||
|
|
||
|
|
||
|
|
Strain Name：B6;129S-Tet1tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00075
|
|
|
|
Strain Name：C57BL/6Smoc-Tet2em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190055
Disease Connection：myelodysplastic syndrome
|
|
|
|
Strain Name：C57BL/6Smoc-Tet3tm1.1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-18002
Research Application：Epigenetic,DNA demethylation study
|
|
|
|
Strain Name：C57BL/6Smoc-Tet3em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-18003
Research Application：Epigenetic,DNA demethylation study
|
