In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Stim1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2101327
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Strain Name：C57BL/6Smoc-Stk10em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253274
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Strain Name：C57BL/6Smoc-Stk11tm(flox)1Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18014
Disease Connection：endometrial cancer, urinary bladder cancer, Peutz-Jeghers syndrome, skin melanoma
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Strain Name：C57BL/6Smoc-Stk11tm1(flox)Gt(ROSA)26Sorem1(CAG-LSL-Luciferase-2A-EGFP-wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-234717
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Strain Name：C57BL/6Smoc-Stk11tm(flox)1Gt(ROSA)26Sorem1(CAG-LSL-Luciferase-2A-EGFP-wpre-polyA)Krasem4(LSL-G12D)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-234719
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Strain Name：C57BL/6Smoc-Stk11em1(frox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200251
Disease Connection：endometrial cancer, urinary bladder cancer, Peutz-Jeghers syndrome, skin melanoma
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