In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Bmi1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-210189
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Strain Name：C57BL/6Smoc-Bmp1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200065
Disease Connection：osteogenesis imperfecta
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Strain Name：C57BL/6Smoc-Bmp10em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-233996
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Strain Name：C57BL/6Smoc-Bmp2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200344
Research Application：Brachydactyly；a malformed index finger and second toe
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Strain Name：C57BL/6Smoc-Bmp4em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-240127
Disease Connection：atrioventricular septal defect, physical disorder
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Strain Name：C57BL/6Smoc-Bmp5em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2102442
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Strain Name：C57BL/6Smoc-Bmp7em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
Disease Connection：osteoarthritis
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