Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

Mice
Strain Name:C57BL/6Smoc-Slc30a4em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-253475
Mice
Strain Name:C57BL/6Smoc-Slc30a5em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6Smoc-Slc30a6em1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-253645
Mice
Strain Name:C57BL/6Smoc-Slc30a7em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6JSmo-Slc30a8em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-233903
Mice
Strain Name:C57BL/6Smoc-Slc30a9em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
Mice
Strain Name:C57BL/6JSmo-Slc31a1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-226434
Mice
Strain Name:C57BL/6JSmo-Slc31a2em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-226408
Mice
Strain Name:C57BL/6JSmo-Slc32a1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-200219
Research Application:The study of synaptic vesicle cycle and GABAergic synapse
Mice
Strain Name:C57BL/6JSmo-Slc33a1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-241561
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