In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6JSmo-Sirpb1aem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-233902
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Strain Name：C57BL/6JSmo-Sirpdem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-231917
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Strain Name：C57BL/6JSmo-Sirt1tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190037
Disease Connection：fatty liver disease
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Strain Name：C57BL/6JSmo-Sirt2tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-190038
Research Application：Epigenetic
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Strain Name：C57BL/6JSmo-Sirt3tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190039
Research Application：Epigenetic
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Strain Name：C57BL/6JSmo-Sirt4em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200243
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Strain Name：C57BL/6JSmo-Sirt5em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200244
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Strain Name：C57BL/6JSmo-Sirt6em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200241
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