In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6JSmo-Shfem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-240356
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Strain Name：C57BL/6Smoc-Shflem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-253642
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Strain Name：C57BL/6JSmo-Shhem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2101338
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Strain Name：C57BL/6JSmo-Shisa5tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-190072
Research Application：Diseases associated with SHISA5 include Vasculopathy, Retinal, With Cerebral Leukodystrophy and Aicardi-Goutieres Syndrome 1.
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