In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6JSmo-Rb1tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18012
Disease Connection：retinoblastoma, osteosarcoma, pancreatic carcinoma, medulloblastoma
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Strain Name：C57BL/6JSmo-Rb1tm1(flox)Trp53tm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-232461
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Strain Name：C57BL/6JSmo-Rb1tm1(flox)Trp53tm2(flox)Gt(ROSA)26Sorem1(CAG-LSL-Luciferase-2A-EGFP-wpre-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-234513
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Strain Name：C57BL/6JSmo-Rb1cc1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-233768
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