In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
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Strain Name：C57BL/6Smoc-Prkag2os1em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
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Strain Name：C57BL/6JSmo-Prkar1atm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-240915
Disease Connection：Carney complex, thyroid gland follicular carcinoma, osteosarcoma, primary pigmented nodular adrenocortical disease
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Strain Name：C57BL/6JSmo-Prkar2bem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-260120
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Strain Name：C57BL/6JSmo-Prkcaem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-210146
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