Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

mouse
Strain Name:C57BL/6Smoc-Pnmtem1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6JSmo-Pnnem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-241431
mouse
Strain Name:C57BL/6JSmo-Pno1em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-250616
mouse
Strain Name:C57BL/6Smoc-Pnocem1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6JSmo-Pnpem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231981
mouse
Strain Name:C57BL/6JSmo-Pnpem1(flox)Nkx2-1em1(CreERT2-pA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-XA-234815
mouse
Strain Name:C57BL/6JSmo-Pnp2em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-232491
mouse
Strain Name:C57BL/6Smoc-Pnpla1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6JSmo-Pnpla2em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-200207
Research Application:Research on Respiratory Electronic Transport
mouse
Strain Name:C57BL/6JSmo-Pnpla3em1(flox)Smoc
Strain State:Developing | Cat. NO.:NM-CKO-262046
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