Tmem119-2A-CreERT2

Nomenclature

C57BL/6Smoc-Tmem119em2(P2A-CreERT2)Smoc

Cat. NO.

NM-KI-200234

Strain State

Repository Live

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Gene Summary

Gene Symbol
Tmem119

Synonyms

obif; AW208946; BC025600

NCBI ID

231633

MGI ID

2385228

Ensembl ID

ENSMUSG00000054675

Pubmed

Tmem119

Human Ortholog

TMEM119

Model Description

将P2A-CreERT2共表达结构插入到小鼠Tmem119基因终止密码子处。
Research Application：Cre工具鼠；小胶质细胞

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Validation Data

图片4-1.png

图片5.png图片6.png图片7.png图1 Tmem119-CreERT2小鼠在小胶质细胞中具有高表达。

A. 经Tamoxifen和玉米油分别处理，荧光检测Tmem119-CreER；R26-tdTomato小鼠中tdTomato的表达情况。

B. 荧光检测Tmem119-CreER；R26-tdTomato小鼠IBA1 阳性细胞中有tdTomato的表达。

C. 荧光检测Tmem119-CreER；R26-tdTomato小鼠小胶质细胞（Tmem119，Tdtomato）与星形胶质细胞（GFAP, green）共定位。

D. 荧光检测Tmem119-CreER；R26-tdTomato小鼠小胶质细胞（Tmem119，Tdtomato）与神经元（NeuN, green）共定位。

（Scale bar=10μm Hippo: Hippocampus; Str: Striatum; Sn: Substantia nigra.)

image.png

表1 Tmem119-CreERT2小鼠标记的小胶质细胞的定量分析。

Publications 3piece

1. Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function
Published year：2024-03-26 References：Cell Reports

2. The m6A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia
Published year：2024 References：CELL DEATH AND DIFFERENTIATION

3. Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization
Published year：2023-07-24 References：PLOS BIOLOGY

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