hCFTR

Nomenclature

C57BL/6Smoc-Cftrtm1(hCFTR)Smoc

Cat. NO.

NM-HU-225060

Strain State

Repository Live

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Gene Summary

Gene Symbol
Cftr

Synonyms

Abcc7; AW495489

NCBI ID

12638

MGI ID

88388

Ensembl ID

ENSMUSG00000041301

Pubmed

Cftr

Human Ortholog

CFTR

Model Description

The endogenous mouse Cftr gene was replaced by human CFTR gene.

Validation Data

image.png

Fig.1 Detection of CFTR expression in testis by RT-PCR. 

Wild type: only one band at 209 bp with primers F1/R1(mCftr);

Homozygous: only one band at 227 bp with primers F2/R2(hCFTR).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human CFTR expression in hCFTR knockin mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous; PC, positive control, HepG2 cells.

Note. The anti-human CFTR antibody cross-reacted with mouse and humanized CFTR.


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