hCD19

Nomenclature

C57BL/6Smoc-Cd19em1(hCD19) Smoc

Cat. NO.

NM-HU-00110

Strain State

Repository Live

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Gene Summary

Gene Symbol
CD19

Model Description

The endogenous mouse Cd19 gene was replaced by human CD19 gene .
Research Application:Immunotherapy,cancer research,drug screening

Validation Data

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Fig.1 Expression characterization of hCD19 on B cells in blood in hCD19 KI mice.

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Fig.2 Expression characterization of hCD19 on B cells in spleen in hCD19 KI mice.

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Fig.3 Expression characterization of hCD19 on B cells in thymus in hCD19 KI mice.

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Fig.4 Body weight and ratios of spleen, thymus and MLN to body weight of 8-week-old hCD19 knokcin mice. (n=6 for all groups, Mean±SEM, Unpaired t-test, *P<0.05, **P<0.01).

Abbr. HO, homozygous; WT, wild type; MLN, mesenteric lymph nodes.

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Table 1. Blood routine examination of hCD19 knockin mice. Values are expressed as mean±SEM.

Abbr. HO, homozygous; WT, wild type.

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Table 2. Biochemical test of serum from hCD19 knockin mice. Values are expressed as mean±SEM.

Abbr. HO, homozygous; WT, wild type.

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Fig.5 Blood biochemical detection of 8-week-old hCD19 knokcin mice. (n=6 for all groups, Mean±SEM).

Abbr. HO, homozygous; WT, wild type.

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Fig.6 Detection of myeloid cell subsets in the blood of 8-week-old hCD19 knockin mice by FACS (n=3 in all groups).

Abbr.  WT, wild type; HO, homozygous.

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Fig.7 Detection of lymphocyte subsets in the blood of 8-week-old hCD19 knockin mice by FACS (n=3 in all groups).

Abbr.  WT, wild type; HO, homozygous.

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Fig.8 Detection of myeloid cell subsets in the spleen of 8-week-old hCD19 knockin mice by FACS (n=3 in all groups).

Abbr.  WT, wild type; HO, homozygous.

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Fig.9 Detection of lymphocyte subsets in the spleen of 8-week-old hCD19 knockin mice by FACS (n=3 in all groups).

Abbr.  WT, wild type; HO, homozygous.


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