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Models

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Mice

hIL4-Tg(NMG)(2)

Strain Name：NOD.Cg-PrkdcscidIl2rgem2Tg(hIL4)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-220132
Validation Data：Presence

These transgenic mice carry humanized IL4.While hIL4-Tg(NMG)(Stock No.NM-KI-215004) mice function similarly to hIL4-Tg(NMG)(2) mice, for more detailed information please contact our technical advisor.

Mice

hIL1RL2

Strain Name：C57BL/6JSmo-Il1rl2tm1(hIL1RL2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215057

The endogenous mouse Il1rl2 gene was replaced by human IL1RL2 gene.

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6JSmo-Tnfrsf4tm3(hTNFRSF4)Ctla4tm1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hPD-L1(2)/hCCR8

Strain Name：C57BL/6JSmo-Cd274tm2(hPD-L1)Ccr8tm1(hCCR8)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210401

hPD-1(2)(NM-HU-190039) was crossed with hCCR8(NM-HU-190053) to generate hPD-L1(2)/hCCR8 mice.

Mice

hMARCO

Strain Name：C57BL/6JSmo-Marcotm1(hMARCO)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000029
Validation Data：Presence

The endogenous mouse Marco gene was replaced by human MARCO gene.

Mice

hIL17RA

Strain Name：C57BL/6JSmo-Il17ratm1(hIL17RA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190049
Validation Data：Presence

The endogenous mouse Il17ra gene was replaced by human IL17RA gene.

Mice

R26-CAG-LNL-CaMPARI

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LNL-CaMPARI)-NSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00090

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven CaMPARI gene. The targeted mutation was inserted into the Gt(ROSA)26Sor locus by homologous recombination.

Mice

Il33-KO(2)

Strain Name：C57BL/6JSmo-Il33em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190436
Validation Data：Presence  |  Publications：1piece

Il33-KO(2) mice(Stock No.NM-KO-190436) carry a knockout allele derived from the targeted deletion of exon 3-7. While Il33-KO mice(Stock No.NM-KO-00099) have been pulled from shelves for some reasons and Il33-KO(3) mice(Stock No.NM-KO-210206) carrying the exon 2 deletion.

Mice

Cx3cr1-Cre

Strain Name：C57BL/6JSmo-Cx3cr1em1(iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200079
Validation Data：Presence

The coding region of Cx3cr1 gene was replaced by a iCre expression cassette via CRISPR/Cas9 mediated recombination.

Mice

hIL13(BALB/c)

Strain Name：BALB/cJSmo-Il13tm2(hIL13)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220019
Validation Data：Presence

The endogenous mouse Il13 gene was replaced by human IL13 gene.

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