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Models

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Mice

R26-CAG-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Luc-EGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00087
Validation Data：Presence

This R26-(CAG-Luc-EGFP) strain was generated by crossing R26-(CAG-LSL-Luc-EGFP)(NM-KI-190095) mice with Ddx4-Cre mice.

Mice

A4galt-KO

Strain Name：C57BL/6Smoc-A4galtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200001
Validation Data：Absence

Exon 3 of A4galt gene was deleted to generate A4galt knockout mice.

Mice

Calb1-2A-GFPCre

Strain Name：C57BL/6Smoc-Calb1em1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200141
Validation Data：Presence

A 2A-EGFP-Cre expression cassette was knocked into the Calb1 gene stop codon site. Calb1 is highly expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful in studying many neurobehavioral diseases such as spatial learning and circadian rhythm interference. It has been reported that the incidence of many diseases may be different between genders.

Mice

hIL1RAP

Strain Name：C57BL/6Smoc-Il1rapem3(hIL1RAP)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000070
Validation Data：Presence

The endogenous mouse Il1rap gene was replaced by human IL1RAP gene.

Mice

A26C3-KO

Strain Name：C57BL/6Smoc-A26C3em1Smoc
Strain State：Developing | Cat. NO.：TBD
Validation Data：Absence

Exon 2 of A26C3 gene was deleted to generate A26C3 knockout mice.

Mice

hIL12RB2

Strain Name：C57BL/6Smoc-Il12rb2em(hIL12RB2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-215019
Validation Data：Presence

The endogenous mouse Il12rb2 gene was replaced by human IL12RB2 gene.

Mice

hNR1I2

Strain Name：C57BL/6Smoc-Nr1i2em3(hNR1I2)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000066
Validation Data：Presence

The endogenous mouse Nr1i2 gene was replaced by human NR1I2 gene.

Mice

hPD-1/hCD40

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd40em1(hCD40)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190017
Validation Data：Absence

hPD-1(NM-HU-00015) was crossed with hCD40(NM-HU-00076) to generate hPD-1/hCD40.

Mice

hPD-L1(2)/hCD28

Strain Name：C57BL/6Smoc-Cd274em2(hPD-L1)Cd28em2(hCD28)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210370
Validation Data：Absence

hPD-L1(2)(NM-HU-190039) was crossed with hCD28(NM-HU-190011）to generate hPD-L1(2)/hCD28 mice

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105
Validation Data：Absence

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

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