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Models

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Mice

hCTLA-4/4-1BB

Strain Name：C57BL/6Smoc-Ctla4tm1(hCTLA4) Tnfrsf9tm1(hTNFRSF9) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18020

This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Crbn-I391V/Rag2-KO

Strain Name：C57BL/6Smoc-Crbnem1(I391V)Rag2em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210398

Crbn-I391V(NM-KI-200331) was crossed with Rag2-KO(NM-KO-190429) to generate Crbn-I391V/Rag2-KO mice.

Mice

hPD-1/hIL1B

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Il1btm3(hIL1B)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210018

hPD-1(NM-HU-00015) was crossed with hIL1B(NM-HU-190047) to generate hPD-1/hIL1B mice

Mice

hDLL4

Strain Name：C57BL/6Smoc-Dll4tm1(hDLL4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000020
Validation Data：Presence

The endogenous mouse Dll4 gene was replaced by human DLL4 gene.

Mice

Ly6g-2A-DTRGFP(BALB/c)

Strain Name：BALB/cAnSmoc-Ly6gem(2A-DTRGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-204997
Validation Data：Presence

2A-DTRGFP expression cassette was knocked into the Ly6g gene .

Mice

hIL1RL2

Strain Name：C57BL/6Smoc-Il1rl2tm1(hIL1RL2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215057

The endogenous mouse Il1rl2 gene was replaced by human IL1RL2 gene.

Mice

Il11-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il11em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00036

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il11.

Mice

hCTLA-4/hTIGIT

Strain Name：C57BL/6Smoc-Ctla4tm1(hCTLA4)Tigittm1(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210399

hCTLA4(NM-HU-00014) was crossed with hTIGIT(NM-HU-00053) to generate hCTLA4/hTIGIT mice.

Mice

hSERPINH1

Strain Name：C57BL/6Smoc-Serpinh1tm1(hSERPINH1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225081
Validation Data：Presence

The endogenous mouse Serpinh1 gene was replaced by human SERPINH1 gene.

Mice

Ins2-C96Y

Strain Name：C57BL/6Smoc-Ins2em3(C96Y)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190096
Validation Data：Presence

These mice carry a p.C96Y mutation of Ins2 gene.

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