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Models

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Mice

Abcb8-Flox

Strain Name：C57BL/6Smoc-Abcb8em1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-253536
Validation Data：Absence

These mice carry loxP sites flanking exon 3-6 of Abcb8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Abcb8 gene.

Mice

hLILRB4

Strain Name：C57BL/6Smoc-Lilrb4aem1(hLILRB4 )Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210024
Validation Data：Presence

The endogenous mice Lilrb4a gene was completely or partially replaced by human LILRB4 gene via CRISPR/Cas9 mediated recombination.

Mice

R26-CAG-2xKRAB-dCas9-IRES-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-Loxp-2xKRAB-dCas9-IRES-EGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18007
Validation Data：Presence

These mice harbor a CAG-LSL-2xKRAB-dCas9-IRES-EGFP-WPRE-pA conditional expression cassette in mouse Rosa26 loci via homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional inhibition (CRISPRi). The loxp-stop-loxp cassette was deleted.

Mice

hIL13(BALB/c)

Strain Name：BALB/cAnSmoc-Il13em2(hIL13)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220019
Validation Data：Presence

The endogenous mouse Il13 gene was replaced by human IL13 gene.

Mice

Atrn-2A-Cre

Strain Name：C57BL/6Smoc-Atrnem(2A-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215077
Validation Data：Absence

2A-Cre expression cassette was knocked into the Atrn gene .

Mice

Abcc2-KO

Strain Name：C57BL/6Smoc-Abcc2em3Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18017
Validation Data：Absence

Exon4-6 of Abcc2 gene were deleted to generate Abcc2 knockout mice.

Mice

Itgam-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Itgamem1(IRES-DTR-EGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200066
Validation Data：Presence

A IRES-DTR-EGFP expression cassette was knocked into the Itgam gene stop codon site.

Mice

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Strain State：Developing | Cat. NO.：NM-NSG-003
Validation Data：Absence

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

Mcpt8-2A-CreERT2

Strain Name：C57BL/6Smoc-Mcpt8em1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200006
Validation Data：Presence

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Mcpt8 gene stop codon site.

Mice

Nmu-2A-Cre

Strain Name：C57BL/6Smoc-Nmuem1(2A-Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200298
Validation Data：Presence

2A-Cre-WPRE-polyA expression cassette was knocked into the Nmu gene stop codon site. Nmu gene encodes a member of the neuromedin family of neuropeptides. The encoded protein plays a role in energy homeostasis and body temperature regulation. And the protein is homologous with human NMU, which is linked toobesity.

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