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Models

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Mice

hIL1RAP

Strain Name：C57BL/6Smoc-Il1raptm3(hIL1RAP)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000070
Validation Data：Presence

The endogenous mouse Il1rap gene was replaced by human IL1RAP gene.

Mice

hPD-L1(2)/hCCR8

Strain Name：C57BL/6Smoc-Cd274tm2(hPD-L1)Ccr8tm1(hCCR8)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210401

hPD-1(2)(NM-HU-190039) was crossed with hCCR8(NM-HU-190053) to generate hPD-L1(2)/hCCR8 mice.

Mice

Itgam-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Itgamem1(IRES-DTR-EGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200066
Validation Data：Presence

A IRES-DTR-EGFP expression cassette was knocked into the Itgam gene stop codon site.

Mice

Nkx3-1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Nkx3-1em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200071
Validation Data：Presence

A IRES-CreERT2 expression cassette was knocked into the Nkx3-1 gene stop codon site.

Mice

Procr-DreERT2

Strain Name：C57BL/6Smoc-Procrem1(kozak-DreER-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200201

A kozak-DreER-WPRE-pA expression cassette was knocked into the Procr gene start codon site.

Mice

hPD-1/hCD40

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd40tm1(hCD40)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190017

hPD-1(NM-HU-00015) was crossed with hCD40(NM-HU-00076) to generate hPD-1/hCD40.

Mice

IL1B-Luc-Tg

Strain Name：B6.Cg-Tg(IL1B-Luc)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00001
Validation Data：Presence  |  Publications：1piece

The transgenic mice model could be used to study transcriptional regulation of the IL-1βgene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4)Ctla4tm1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Lgr5-2A-DreERT2

Strain Name：C57BL/6Smoc-Lgr5em1(2A-DreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200178
Validation Data：Presence  |  Publications：1piece

A 2A-DreERT2 expression cassette was knocked into the Lgr5 gene stop codon site.

Mice

hIL13(BALB/c)

Strain Name：BALB/cAnSmoc-Il13tm2(hIL13)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220019
Validation Data：Presence

The endogenous mouse Il13 gene was replaced by human IL13 gene.

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