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Models

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Mice

Lepr-KO

Strain Name：C57BL/6Smoc-Leprem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190663
Validation Data：Absence

Exon 5 of Lepr gene was deleted to generate Lepr knockout mice.

Mice

Il10-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Il10em4Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200637
Validation Data：Absence

Exon 1-5 of Il10 gene was deleted to generate Il10 knockout mice.

Mice

hIL7R

Strain Name：C57BL/6Smoc-Il7rem1(hIL7R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210027
Validation Data：Absence

The endogenous mice Il7r gene was completely or partially replaced by human IL7R gene via ESC targeting.

Mice

Il17f-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il17fem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00031
Validation Data：Absence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il17f.

Mice

hPD-1/hPD-L1/hTIM3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200264
Validation Data：Absence

hTIM3（NM-HU-00054）,hPD-1（NM-HU-00015）,hPD-L1（NM-HU-00062）were crossed together to generate hPD-1/hPD-L1/hTIM3 mice

Mice

hCFTR

Strain Name：C57BL/6Smoc-Cftrem1(hCFTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225060
Validation Data：Presence

The endogenous mouse Cftr gene was replaced by human CFTR gene.

Mice

Etv1-CreERT2

Strain Name：C57BL/6Smoc-Etv1em1(CreERT2-SV40-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200105
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Mice

Trp63-CreERT2

Strain Name：C57BL/6Smoc-Trp63em(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225021
Validation Data：Presence

A CreERT2-Wpre-polyA expression cassette was knocked into the exon4 of Trp63 gene via CRISPR/Cas mediated recombination.

Mice

hFCRN(3)

Strain Name：C57BL/6Smoc-Fcgrtem3(hFCGRT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000032
Validation Data：Absence

The endogenous mouse Fcgrt gene was replaced by human FCGRT gene. While hFCRN(Stock No.NM-HU-00109）and hFCRN(2)(Stock No.NM-HU-190070) mice function similarly to hFCRN(3) mice,for more detailed information please contact our technical advisor.

Mice

hPD-1/hSEMA4D

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Sema4dem1(hSemA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190033
Validation Data：Absence

hPD-1(NM-HU-00015) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-1/hSEMA4D.

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