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Models

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Mice

hCD3EDG/hCD28

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd28tm2(hCD28)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220113
Validation Data：Presence

hCD3EDG(NM-HU-220120) mice were crossed with hCD28(NM-HU-190011) to generate hCD3EDG/hCD28 mouse

Mice

hGNRHR

Strain Name：C57BL/6Smoc-Gnrhrtm(hGNRHR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220137
Validation Data：Presence

The endogenous mouse Gnrhr gene was replaced by human GNRHR gene.

Mice

Snca-KO

Strain Name：C57BL/6Smoc-Sncaem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190380

This Snca knockout mouse model was generated by knocking out the exon4 region of the Snca.

Mice

hIL1A

Strain Name：C57BL/6Smoc-Il1atm1(hIL1A)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215071
Validation Data：Presence

The endogenous mouse Il1a gene was replaced by human IL1A gene.

Mice

hICOS

Strain Name：C57BL/6Smoc-Icostm1(hICOS)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00052
Validation Data：Presence

The endogenous mouse Icos gene was replaced by human ICOS gene. While hICOS(2)(Stock No.NM-HU-190030) mice function similarly to hICOS mice,for more detailed information please contact our technical advisor.

Mice

Foxp3-DreERT2

Strain Name：C57BL/6Smoc-Foxp3em5(IRES-DreER)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200198

A IRES-DreER expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

hPD-L1/hSIGLEC15

Strain Name：C57BL/6Smoc-Cd274tm1(hCD274)Siglec15tm1(hSIGLEC15)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000103

hPD-L1(NM-HU-00062) was crossed with hSIGLEC15(NM-HU-190037) to generate hPD-L1/hSIGLEC15.

Mice

R26-CAG-LSL-hPIK3CA*H1047R-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-PIK3CA(H1047R)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190065

These mice harbor a CAG-LSL-PIK3CA(H1047R)-IRES-luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hSERPINC1

Strain Name：C57BL/6Smoc-Serpinc1tm1(hSERPINC1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225075
Validation Data：Presence

The endogenous mouse Serpinc1 gene was replaced by human SERPINC1 gene.

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