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Models

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Mice

hTIGIT(BALB/c,2)

Strain Name：BALB/cAnSmoc-Tigitem4(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200245
Validation Data：Presence

The endogenous mice Tigit gene was replaced by human TIGIT gene.While hTIGIT(BALB/c) (Stock No.NM-HU-2000043) have been pulled from shelves for some reasons.

Mice

hSIGLEC9

Strain Name：C57BL/6Smoc-Sigleceem1(hSIGLEC9)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225072
Validation Data：Absence

The endogenous mouse Siglece gene was replaced by human SIGLEC9 gene.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpaem2(hSIRPA)Cd47em1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hDMPK

Strain Name：C57BL/6Smoc-Dmpkem1(hDMPK)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225084
Validation Data：Presence

The endogenous mouse Dmpk gene was replaced by human DMPK gene.

Mice

hAPOE3

Strain Name：C57BL/6Smoc-Apoeem3(hAPOE3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190003
Validation Data：Presence

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

hPD-1(BALB/c)

Strain Name：BALB/cAnSmoc-Pdcd1em1(hPDCD1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190079
Validation Data：Presence

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .

Mice

hPSGL-1(2)

Strain Name：C57BL/6Smoc-Selplgem2(hSELPLG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210026
Validation Data：Presence

The endogenous mice Selplg gene was completely or partially replaced by human SELPLG gene via CRISPR/Cas9 mediated recombination.

Mice

Pvalb-2A-mCherry

Strain Name：C57BL/6Smoc-Pvalbem(2A-mCherry)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220177
Validation Data：Absence

2A-mCherry expression cassette was knocked into the Pvalb gene stop codon site.

Mice

Bag3-Flox

Strain Name：C57BL/6Smoc-Bag3em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2101856
Validation Data：Absence

These mice carry loxP sites flanking exon 4 of Bag3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bag3 gene.

Mice

Col1a1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Col1a1em(IRES-CreERT2)1Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225031
Validation Data：Presence

IRES-CreERT2 expression cassette was knocked into the Col1a1 gene. The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

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