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Models

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Mice

Myf5-Cre

Strain Name：C57BL/6Smoc-Myf5em1(Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200147
Validation Data：Presence

A Cre-WPRE-polyA expression cassette was knocked into the Myf5 gene start codon site. Myogenic factor 5 (Myf5) belongs to the MRF family transcription factors that regulate myogenesis. It is expressed in the skeletal muscle and satellite cells. Severe loss of skeletal muscle following ablation of Myf5-expressing progenitors. This strain is useful in studying the differentiation of skeletal muscle.

Mice

hPD-1/hSEMA4D

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Sema4dtm1(hSemA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190033

hPD-1(NM-HU-00015) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-1/hSEMA4D.

Mice

Nkx2-5-IRES-Cre

Strain Name：C57BL/6Smoc-Nkx2-5em1(IRES-Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200152
Validation Data：Presence

A IRES-Cre-WPRE-polyA expression cassette was knocked into the Nkx2-5 gene stop codon site.

Mice

Mc4r-2A-Cre

Strain Name：C57BL/6Smoc-Mc4rem1(T2A-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200220
Validation Data：Presence

A T2A-Cre expression cassette was knocked into the Mc4r gene stop codon site.

Mice

hIL11

Strain Name：C57BL/6Smoc-Il11tm1(hIL11)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204981

The endogenous mice Il11 gene was replaced by human IL11 gene.

Mice

Bmi1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Bmi1em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200095
Validation Data：Presence

A IRES-CreERT2 expression cassette was knocked into the Bmi1 gene stop codon site.

Mice

R26-CAG-LSL-hEGFR*L858R-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-EGFR (L858R)-IRES-Luciferase-2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190069

These mice harbor a CAG-LSL-EGFR(L858R)-IRES-Luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

Prkdc/Il2rg-KO(NOD)

Strain Name：NOD-Prkdcem1 Il2rgem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00158

Prkdc and Il2rg double knockout mice were generated.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001
Validation Data：Presence

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

hIL9(BALB/c)

Strain Name：BALB/cAnSmoc-Il9tm3(hIL9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220012
Validation Data：Presence

The endogenous mouse Il9 gene was replaced by human IL9 gene.

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