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Models

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Mice

hGLP1R

Strain Name：C57BL/6JSmo-Glp1rtm2(hGLP1R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200220
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Glp1r gene was completely or partially replaced by human hGLP1R gene via CRISPR/Cas9 mediated recombination.

Mice

hCSF1

Strain Name：C57BL/6JSmo-Csf1tm2(CSF1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190043
Validation Data：Presence

The endogenous mouse Csf1 gene was replaced by human CSF1 gene.

Mice

Shh-EGFP-Cre

Strain Name：C57BL/6JSmo-Shhem1(EGFP-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200232
Validation Data：Presence

A EGFP-iCre expression cassette was knocked into the Shh gene start codon site.

Mice

Batf3-KO

Strain Name：C57BL/6JSmo-Batf3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190447

exon 1-2 of Batf3 gene was deleted to generate Batf3 knockout mice.

Mice

KPC

Strain Name：C57BL/6JSmo-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096
Validation Data：Presence

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

hB7H4

Strain Name：C57BL/6JSmo-Vtcn1tm1(hVTCN1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190004

This VTCN1 humanized mouse model was established by replacing the mouse Vtcn1 gene with the human VTCN1. While hB7H4(2)(Stock No.NM-HU-190075) mice function similarly to hB7H4 mice,for more detailed information please contact our technical advisor.

Mice

Braf-Flox-V600E

Strain Name：C57BL/6JSmo-Brafem1(flox-V600E)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190053

These mice carry a conditional p.V600E mutation of Braf gene.

Mice

H11-pAlb-hALB-IRES-Luc

Strain Name：C57BL/6JSmo-Igs2tm1(ALB promoter-human ALB-IRES-Luciferase-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200322

An ALB promoter-human ALB-IRES-Luciferase-polyA expression cassette was knocked into the H11 locus.

Mice

Zbtb46-2A-CreERT2

Strain Name：C57BL/6JSmo-Zbtb46em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18021
Validation Data：Presence

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Zbtb46 gene via homologous recombination to establish a tamoxifen inducible Zbtb46-CreERT2 tool stain. This strain can be used to knockout target gene in Zbtb46+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6JSmo-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence  |  Publications：2piece

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

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