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U-GEMMs

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Mice

Aqp5-2A-CreERT2

Strain Name:C57BL/6Smoc-Aqp5em1(2A-CreERT2-Wpre-pA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200313

2A-CreERT2-Wpre-pA expression cassette was knocked into the Aqp5 gene stop codon site.

Mice

hIL2/hIL2RA(BALB/c)

Strain Name:BALB/cAnSmoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-220018

The endogenous mouse Il2 and Il2ra gene was replaced respectively by human IL2 and IL2RA gene.

Mice

R26-CAG-LNL-ddCas9

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LNL-ddCas9)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-00063

These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven ddCas9. The targeted mutation was inserted into the Gt(ROSA)26Sor locus.

Mice

Grp-Cre

Strain Name:C57BL/6Smoc-Grpem1(Cre-WPRE-pA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200305

Cre-WPRE-pA expression cassette was knocked into the Grp gene start codon site.

Mice

Wt1-CreERT2

Strain Name:C57BL/6Smoc-Wt1em1(CreERT2-WPRE-pA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200127

A CreERT2-WPRE-pA expression cassette was knocked into the Wt1 gene start codon site.

Mice

Sidt2-Flox

Strain Name:B6;129S-Sidt2tm1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-00041

The Sidt2 flox allele has loxP sites flanking exon 2 of Sidt2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Aldh1L2-KO

Strain Name:C57BL/6Smoc-Aldh1L2em1Smoc
Strain State:Developing | Cat. NO.:TBD

Exon 2 of Aldh1L2 gene was deleted to generate Aldh1L2 knockout mice.

Mice

hIL1B(BALB/c)

Strain Name:BALB/cAnSmoc-Il1btm3(hIL1B)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-220017

The endogenous mouse Il1b gene was replaced by human IL1B gene.

Mice

NOD SCID

Strain Name:NOD.Cg-Prkdcscid/NifdcSmoc
Strain State:Repository Live | Cat. NO.:SM-019

The scid mutation has been transferred onto a diabetes-susceptible Non-Obese Diabetic (NOD) background. NOD-Scid mice do not develop diabetes, lack T and B cells, and are inherently immune deficient, making them good recipients for transplantation of human hematopoietic stem cells and human solid tumors. 

Mice

R26-CAG-LSL-hIDH2*R140Q-IRES-Luc-2A-tdTomato

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-IDH2(R140Q)-IRES-Luciferase-2A-tdTomato)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-190075

These mice harbor a CAG-LSL-IDH2(R140Q)-IRES-Luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

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