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U-GEMMs

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Mice

MHC ClassII(I-A/I-E)-KO(NMG)

Strain Name:NOD-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Strain State:Developing | Cat. NO.:NM-NSG-003

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.  These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

hCTLA-4(BALB/c)

Strain Name:BALB/cAnSmoc-Ctla4em1(hCTLA4) Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-190078

Obtained by backcrossing of NM-HU-00014,hCTLA-4 mice.

Mice

A4galt-KO

Strain Name:C57BL/6Smoc-A4galtem1Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-200001

Exon 3 of A4galt gene was deleted to generate A4galt knockout mice.

Mice

hCXCR5

Strain Name:C57BL/6Smoc-Cxcr5em(hCXCR5)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-HU-215007

The endogenous mice Cxcr5 gene was replaced by human CXCR5 gene.

Mice

Adipoq-IRES-Dre

Strain Name:C57BL/6Smoc-Adipoqem(IRES-Dre)1Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-225055

IRES-Dre expression cassette was knocked into the Adipoq gene .

Mice

Cd4-IRES-DTRGFP

Strain Name:C57BL/6Smoc-Cd4em5(IRES-DTREGFP)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-190121

A IRES-DTREGFP expression cassette was knocked into the Cd4 gene stop codon site.

Mice

hSIRPA(2)/hCD47/hCTLA-4

Strain Name:C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)Ctla4em1(hCTLA4) Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210368

hCTLA4(NM-HU-00014) was crossed with hSIRPA(2)/hCD47(NM-HU-2000111)to generate hSIRPA(2)/hCD47/hCTLA4 mice

Mice

Crbn-I391V/Rag2-KO

Strain Name:C57BL/6Smoc-Crbnem1(I391V)Rag2em2Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-210398

Crbn-I391V(NM-KI-200331) was crossed with Rag2-KO(NM-KO-190429) to generate Crbn-I391V/Rag2-KO mice.

Mice

hTIGIT/hCCR8

Strain Name:C57BL/6Smoc-Tigitem1(hTIGIT)Ccr8em1(hCCR8)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210426

hTIGIT(NM-HU-00053) was crossed with hCCR8(NM-HU-190053) to generate hTIGIT/hCCR8 mice.

Mice

hNKG2A/hCD94

Strain Name:C57BL/6Smoc-Nkg2tm1(hNKG2A)Cd94tm1(hCD94)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000016

The endogenous mouse Nkg2 and Cd94 gene was replaced by human NKG2A and CD94 gene.

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