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Models

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Mice

Vip-IRES-Cre

Strain Name：C57BL/6Smoc-Vipem1(IRES-iCre-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200100
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Vip gene stop codon site. Vip encodes vasoactive intestinal polypeptide. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in cells expressing. This strain is useful for studying bronchiectasis, immunomodulatory and anti-inflammatory.

Mice

hPVRL2

Strain Name：C57BL/6Smoc-Nectin2tm1(hNECTIN2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000084
Validation Data：Presence

The endogenous mouse Nectin2 gene was replaced by human PVRL2 gene.

Mice

hAPOE3

Strain Name：C57BL/6Smoc-Apoetm3(hAPOE3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190003
Validation Data：Presence

This APOE3 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE3 corresponding sequence by homologous recombination.

Mice

Casp8-Flox

Strain Name：C57BL/6Smoc-Casp8em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190003

These Casp8 flox mice possess loxP sites flanking exons 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

A4gnt-Flox

Strain Name：C57BL/6Smoc-A4gntem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253848

These mice carry loxP sites flanking exon 1-2 of A4gnt gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A4gnt gene.

Mice

hITGB1

Strain Name：C57BL/6Smoc-Itgb1tm1(hITGB1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225040
Validation Data：Presence

The endogenous mouse Itgb1 gene was replaced by human ITGB1 gene.

Mice

hDMPK

Strain Name：C57BL/6Smoc-Dmpktm1(hDMPK)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225084
Validation Data：Presence

The endogenous mouse Dmpk gene was replaced by human DMPK gene.

Mice

hIL1RL1

Strain Name：C57BL/6Smoc-Il1rl1tm4(hIL1RL1)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-2000067
Validation Data：Presence

The endogenous mouse Il1rl1 gene was replaced by human IL1RL1 gene.

Mice

Slc6a11-CreERT2

Strain Name：C57BL/6Smoc-Slc6a11em1(CreERT2-polyA(SV40)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200130
Validation Data：Presence

A CreERT2-polyA expression cassette was knocked into the Slc6a11 gene start codon site. Slc6a11 encodes GAT3 (Gabt4), a sodium-dependent transporter that uptakes the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which ends the GABA neurotransmission. When Slc6a11-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLC6A11positive cells. Defects in Slc6a11 may result in epilepsy or behavioral and intellectual defects.

Mice

Cd68-IRES-Cre

Strain Name：C57BL/6Smoc-Cd68em1(IRES-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200161

A IRES-Cre expression cassette was knocked into the Cd68 gene stop codon site.

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