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Models

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Mice

hCXCR3

Strain Name：C57BL/6Smoc-Cxcr3em1(hCXCR3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200219
Validation Data：Presence

The endogenous mouse Cxcr3 gene was completely or partially replaced by human CXCR3 gene via ESC targeting.

Mice

Il18-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il18em1(Luc-eGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00032
Validation Data：Presence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il18.

Mice

hIL17A/hIL17F

Strain Name：C57BL/6Smoc-Il17aem1(hIL17A)Il17fem2(hIL17F)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200281
Validation Data：Presence

The endogenous mouse Il17a&Il17f genes were replaced by human IL17A&IL17F gene.

Mice

hIGFBP2

Strain Name：C57BL/6Smoc-Igfbp2em1(hIGFBP2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225085
Validation Data：Absence

The endogenous mouse Igfbp2 gene was replaced by human IGFBP2 gene.

Mice

hTNFR2/hIL2RA

Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Il2ratm1(hIL2RA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210408
Validation Data：Absence

hTNFRSF1B(NM-HU-190010) was crossed with hIL2RA(NM-HU-190064) to generate hTNFRSF1B/hIL2RA mice.

Mice

A1bg-Flox

Strain Name：C57BL/6Smoc-A1bgem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD
Validation Data：Absence

These mice carry loxP sites flanking target exons of A1bg gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A1bg gene.

Mice

Avp-IRES-Cre

Strain Name：C57BL/6Smoc-Avpem1(IRES2-Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200142
Validation Data：Presence

A IRES2-Cre-WPRE-polyA expression cassette was knocked into the Avp gene stop codon site. Avp encodes arginine vasopressin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying hypertension.

Mice

hNCR3

Strain Name：C57BL/6Smoc-Ncr1em1(hNCR3)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215066
Validation Data：Presence

The endogenous mouse Ncr1 gene was replaced by human NCR3 gene.

Mice

Tnnt2-dCreERT2

Strain Name：C57BL/6Smoc-Tnnt2em1(rox-CreERT2-wpre-polyA-rox-tdTomato-wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200015
Validation Data：Absence

A rox-CreERT2-wpre-polyA-rox-tdTomato-wpre-polyA expression cassette was knocked into the Tnnt2 gene start codon site.

Mice

A1Cf-KO

Strain Name：C57BL/6Smoc-A1Cfem1Smoc
Strain State：Developing | Cat. NO.：TBD
Validation Data：Absence

Exon 4 of A1Cf gene was deleted to generate A1Cf knockout mice.

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