Lat-Y136F
Nomenclature
C57BL/6Smoc-Latem1(Y136F）Smoc
Cat. NO.
NM-KI-200249
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
Lat
Model Description
These mice carry a p.Y136F mutation of Lat gene.
Research Application：IgG4-related diseases
*Literature published using this strain should indicate: Lat-Y136F mice (Cat. NO. NM-KI-200249) were purchased from Shanghai Model Organisms Center, Inc..
Validation Data
Fig 1. Spleen (left) and mesenteric lymph nodes (right) from 8-week-old wild-type and Lat-Y136F mice.
Fig 2. Flow cytometry analysis of different subsets of T cells across tissues in homozygous Lat-Y136F mice in mesenteric lymph nodes (MLN) (n=3).
Fig 3. Flow cytometry analysis of different subsets of T cells across tissues in homozygous Lat-Y136F mice in peripheral blood (n=3).
Fig 4. Flow cytometry analysis of different subsets of T cells across tissues in homozygous Lat-Y136F mice in spleen (n=3).
Fig 5. Flow cytometry analysis of different subsets of T cells across tissues in homozygous Lat-Y136F mice in thymus (n=3).
Fig 6. Serum IgG1 and IgE levels in homozygous Lat-Y136F mice (n=3-5).
Fig 7. Histopathological analysis across organs in homozygous Lat-Y136F mice(n=3-4). Scale bar=100 μm; magnification, 200×.
Fig 8. Serum IgG1 level and body weight post 3 weeks treatment in 4/7-week old homozygous Lat-Y136F mice (n=5).
Fig 9. Wet weight and photos of spleen and mesenteric lymph nodes (MLN) upon prednisolone treatment in 7-week old homozygous Lat-Y136F mice (n=5).
Fig. 10 Histopathology changes upon prednisolone treatment. Representative histopathological appearance of kidney and pancreas in 7-week-old prednisolone-treated and saline-treated control mice. Red arrows indicate inflammatory lesions and black arrows indicate fibrosis in the kidney and pancreas of C57 control mice, saline- or prednisolone-treated Lat-Y136F mice (n=5). Data are presented as mean and ± SEM. Scale bar=100 μm; magnification, 200×.
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