Gla-KO

Nomenclature

C57BL/6Smoc-Glaem1Smoc

Cat. NO.

NM-KO-200601

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Gla

Model Description

Exon 2-3 of Gla gene was deleted to generate Gla knockout mice.
Research Application:Fabry Disease research

Validation Data

image.png

Fig1. Detection of Gla expression in brain by RT-PCR (A) and qPCR (B). 

Wild type: only one band at 268 bp with primers F1/R1(mGla).

Abbr. M, DNA marker; WT, wild type.

image.png

Fig2. Detection of serum GLA activity (A) and serum lyso-Gb3 levels (B) in 14 weeks old male Gla-KO mice. (Data from the collaborator)

image.png

Fig3. Hot plate test of 14 weeks old male Gla-KO mice. (Data from the collaborator)


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more