Knockout mouse model is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by deleting portions of the gene’s DNA sequence, or by replacing the gene with an altered DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important clues about the function of individual genes. Mice and humans share many genes in common. Hence, information from knockout mouse models can shed light on the biological roles of specific genes as well as on the involvement of those genes in human disease.
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Strain Name：C57BL/6Smoc-Chrdem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201252
Disease Connection：holoprosencephaly, velocardiofacial syndrome
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Strain Name：C57BL/6Smoc-Chrdl1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200120
Research Application：Therapeutic antibody target
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Strain Name：C57BL/6Smoc-Chrdl1em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-232931
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Strain Name：C57BL/6Smoc-Chrdl2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-205427
Research Application：secreted protein
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Strain Name：C57BL/6Smoc-Chrm1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-191175
Research Application：The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract.
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Strain Name：C57BL/6Smoc-Chrm4em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-191176
Research Application：G protein-coupled receptors
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Strain Name：C57BL/6Smoc-Chrm5em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191177
Research Application：G protein-coupled receptors，mouse studies link its function to adenylyl cyclase inhibition.
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