hIL2/hIL2RA(BALB/c)

Nomenclature

BALB/cAnSmoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc

Cat. NO.

NM-HU-220018

Strain State

Repository Live

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Model Description

The endogenous mouse Il2 and Il2ra gene was replaced respectively by human IL2 and IL2RA gene.

Validation Data

image.png

Fig1. Detection of IL2 expression in splenocyte by RT-PCR. 

Wild type: only one band at 288 bp with primers F1/R1(mIl2);

Homozygous: only one band at 388 bp with primers F2/R2(hIL2);

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig2. Detection of IL2RA expression in splenocyte by RT-PCR. 

Wild type: only one band at 350 bp with primers F1/R1(mIl2ra);

Homozygous: only one band at 318 bp with primers F2/R2(hIL2RA);

Abbr. M, DNA marker; HO, homozygous;WT, wild type.


image.png

Fig3. Detection of hIL2RA expression on splenocyte-derived T cells in hIL2/hIL2RA dKI mice.


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