hIL1B(BALB/c)

Nomenclature

BALB/cAnSmoc-Il1btm3(hIL1B)Smoc

Cat. NO.

NM-HU-220017

Strain State

Embryo cryopreservation

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Model Description

The endogenous mouse Il1b gene was replaced by human IL1B gene.

Validation Data

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Fig1. Detection of IL-1B expression in spleen and lung by RT-PCR. Wild type: only one band at 209 bp with primers F1/R1(mIl-1b);Heterozygous: one band at 209 bp with primers F1/R1(mIl-1b) and one band at 291 bp with primers F2/R2(hIL-1B); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig 2. Detection of hIL1B expression in plasma by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type. Note. hIL1B and Balb/c mice were i.p. injected with LPS(10mg/kg) for 6h.

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