hIL18BP

Nomenclature

C57BL/6Smoc-Il18bpem1(hIL18BP)Smoc

Cat. NO.

NM-HU-210039

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Il18bp

Model Description

The endogenous mice Il18bp gene was replaced by human IL18BP gene.
Research Application:inmmue therapy;drug screening

Validation Data

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Fig1. Detection of IL18BP expression in thymus and liver by RT-PCR. Wild type: only one band at 354 bp with primers F1/R1(mIl18bp);Heterozygous: one band at 354 bp with primers F1/R1(mIl18bp) and one band at 220 bp with primers F2/R2(hIL18BP); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. Detection of IL18BP expression in thymus and liver by RT-PCR.  Wild type: only one band at 354 bp with primers F1/R1(mIl18bp); Homozygous: only one band at 220 bp with primers F2/R2(hIL18BP);  Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig3. Detection of hIL18BP expression in serum by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

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Fig4. Detection of mIL18BP expression in serum by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

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Fig5. Detection of hIL18BP expression in serum by ELISA (n=3). Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

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Fig6. Detection of mIL18BP expression in serum by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type.


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