hIL2/hIL2RA

Nomenclature

C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc

Cat. NO.

NM-HU-200275

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol

Synonyms

Il-2，I， CD25， Il2r， Ly-4， Ly-43

NCBI ID

16183，16184

MGI ID

96548，96549

Ensembl ID

ENSMUSG00000027720，ENSMUSG00000026770

Pubmed

Human Ortholog

IL-2，IL2RA

Model Description

hIL2(NM-HU-190048) was crossed with hIL2R(NM-HU-190064) to generate IhIL2/hIL2RA mice.

Validation Data

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Fig1. Detection of hIL-2 expression by ELISA in the hIL-2 knockin mice (Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).

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Fig2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28 (In collaboration with CrownBio).

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Fig3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on naïve Treg in blood (In collaboration with CrownBio).

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Fig4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA huamnzied mouse (In collaboration with CrownBio).

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Fig5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse (In collaboration with CrownBio).

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